53 The Patient Demographic Details of Referrals for Risk Reducing Breast Surgery and Reconstruction to St Helen’s and Knowsley Teaching Hospitals Over a 5 Year Period

Abstract Background Breast cancer is the most common cause of in women affecting 1 7 UK. Hereditary breast cancers are present up to 10% all cases and commonly related BRCA gene mutations. Bilateral risk reducing mastectomy (RRM) +/- reconstruction effective strategy mortality risk. Reconstruction options can be classified into immediate vs delayed autologous alloplastic reconstruction. Complete may take considerable time depending on waiting lists include additional aesthetic corrections such as lipomodelling nipple Method Retrospective analysis referrals (all ages) a single surgeon at Whiston Hospital for following RRM between 1/04/2015-1/04/2020. Results There were total 467 referrals. Of these, 76 (16%) referred RRM, 51 (67%) these patients had confirmed genetic mutations 24 (32%) no mutation. 48 (94%) carriers which 32 (63%) BRCA2 carriers, 14 (27%) BRCA1 2 with unknown variants. (4%) CHEK2 (2%) patient Cowden’s syndrome. Conclusions currently standardised guidance timing high-risk patients. The increases age, there need stratification tool lists, identify highest development considering their personal family history.